Welcome to DisProt, the database of intrinsically disordered proteins

DisProt is the major manually curated repository of Intrinsically Disordered Proteins, both for structural and functional aspects. Expert curators are involved in collecting experimentally confirmed biological data, valuable for the scientific community, and for updating and maintaining DisProt over time. Learn more DisProt and visit the browse section to explore the data collected in DisProt.

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Datasets
Bacterial virulence-related proteins 76
Age-related disorders proteins 42
RNA-binding proteins 212
Condensates-related proteins 181
NDDs-related proteins 324
Neglected tropical diseases proteins 105
Autophagy-related proteins 109
Cancer-related proteins 181
Viral proteins 230
Extracellular matrix proteins 100
Unicellular toxins and antitoxins 51
Deposition link
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The deposition in DisProt is a process to make available experimental data on intrinsically disordered proteins (IDPs), intrinsically disordered regions (IDRs) or/and their functions. It refers to experimental results that have been published or are submitted for publication as part of scientific studies.

Info
Version: 9.8
Release: 2025_06
Number of entries: 3200

The DisProt database is part of the ELIXIR infrastructure and a service of the IDP Community.

Integrated resources
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How to cite

DisProt in 2024: improving function annotation of intrinsically disordered proteins
Aspromonte MC, Nugnes MV, Quaglia F, Bouharoua A, DisProt Consortium, Tosatto S.C.E and Piovesan D (2023) Nucleic Acids Research, Database Issue.
PubMed:37904585, DOI:10.1093/nar/gkad928

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DisProt 2024_12 - New thematic dataset of Age-related disorders proteins


With this last DisProt thematic dataset, we explore the role of intrinsically disordered proteins (IDPs) in Age-related diseases.

Visit our DisProt Training page to access our courses and materials on how to become a biocurator and how to interpret IDP experimental data, and to find out more about our upcoming training sessions.